Perineural Injection Therapy

Perineural Injection Therapy is a gentle treatment that involves injecting a dextrose-based solution around irritated or inflamed nerves. It is commonly used for chronic pain, nerve sensitivity, tingling, burning sensations, and soft tissue irritation. The goal is to calm nerve inflammation and support natural healing.

This service is offered in AHBA, as a tool to help manage chronic pain. Perineural injection therapy is a series of shallow injections. Pain relief should be felt almost immediately, and there is evidence that it can support a variety of chronic pain conditions.

What is a perineural injection?

A perineural injection is a minimally invasive treatment that targets irritated or inflamed nerves. It involves injecting a solution around the nerve to help reduce pain, inflammation, and nerve sensitivity. It is commonly used for chronic pain, nerve irritation, and musculoskeletal conditions.

What conditions can perineural injections help treat?

Perineural injections may help treat conditions such as neuropathy, nerve entrapment, low back pain, headaches, shingles-related pain, carpal tunnel syndrome, and other chronic nerve-related pain conditions.

Are perineural injections safe, and what should I expect after the procedure?

Perineural injections are generally considered safe when performed by a qualified healthcare provider. Most patients experience minimal discomfort during the procedure. Mild soreness or temporary tenderness at the injection site may occur, but recovery is usually quick, and many patients return to normal activities shortly afterward.

Soothe Nerve Pain, Support Healing

Perineural Injection Therapy (PIT) is a proven safe, effective treatment for patients who may not be candidates for joint replacement surgery or biologic options. Perineural injection therapy treats inflamed and injured nerves. Chronic nerve pain is often due to trauma, arthritis, sports, overuse, occupational, and surgical injuries.

It involves the physician understanding the anatomy of these sensory nerves as they course throughout the body. A series of injections containing the dextrose solution is placed underneath the skin much in the same way as getting a TB test or a “pinprick.” A very short, small needle is used to treat along the course of the nerve.

Benefits of Perineural
Injection Therapy

Many patients experience immediate pain relief, and repeated treatments (typically 6–8 sessions) can provide long-term resolution of chronic pain.

Fast and Lasting Pain Relief

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Unlike general pain relief methods that just mask pain, PIT treats neurogenic inflammation at its source to allow nerves to heal.

Targeted Nerve Treatment

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PIT uses a small, short needle for superficial injections just under the skin (subcutaneously), minimizing the risks associated with deeper injections or surgery.

Safe and Minimally Invasive

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Dextrose 5% (D5W) is used, which acts as an analgesic and is considered very safe with almost no risk of allergic reactions.

Minimal Side Effects

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By reducing nerve inflammation and freeing up trapped or pinched nerves (hydrodissection), it reduces muscle spasms and improves joint motion.

Improves Mobility

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It is an effective option for patients with chronic pain who are not candidates for joint replacement or other aggressive procedures.

Safe Alternative to Surgery

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Targeted Therapy for
Sensitive Nerves

Chronic Nerve Pain

Neuralgia, sciatica, and nerve pain from injury.

Entrapment Neuropathies

Carpal Tunnel Syndrome (CTS), personal neuropathy

Musculoskeletal Pain

Rotator cuff injuries, knee pain, and chronic ankle pain

Chronic Postoperative Pain

Pain that persists after surgeries

Procedure Process of Perineural Injection Therapy

Pre-Procedure	During the Procedure	Post-Procedure
Before starting Perineural Injection Therapy, your provider will evaluate your condition and explain your personalized treatment plan. Most patients benefit from 4–6 sessions spaced 1–4 weeks apart. No pain medications or local anesthetics are required, and you may continue your regular medications, including anti-inflammatory drugs. Patients are encouraged to stay active while avoiding activities that worsen pain.	Perineural Injection Therapy involves small injections of dextrose solution just under the skin near affected nerves. The procedure is generally quick and well tolerated, without the need for anesthesia. You may feel mild discomfort or a slight stinging sensation at the injection sites, but the treatment is typically not painful.	After your first treatment, relief may be temporary, but many patients notice gradual improvement after additional sessions. Pain often becomes less intense and less frequent as treatment continues, helping restore normal function over time. Side effects are uncommon and may include mild bruising at the injection site. Patients are encouraged to stay active while avoiding activities that worsen symptoms.

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